Ginkgo Biloba Medical Uses In dementia

Ginkgo Biloba Medical Uses In dementia
Ginkgo has been proposed as a treatment for Alzheimer's disease on the basis of positive preclinical results in mice and a 2006 study found 160 mg of ginkgo extract to be as effective as a daily 5-mg dose of the cholinesterase inhibitor donepezil in human subjects.

•  A 2008 randomized controlled clinical trial found ginkgo ineffective at treating dementia in humans at a daily dose of 120 mg.
•  A similar trial published in 2010, however, found ginkgo effective at treating mild to moderate dementia at the higher single dose of 240 mg daily.
•  Another randomized controlled trial, published in 2009, found no benefit from ginkgo in preventing cognitive decline or dementia when given at a dose of 120 mg twice daily.
•  A similar study reported in 2012 concluded the long-term use of Ginkgo biloba extract does not affect progression to Alzheimer's disease.
• A recent meta-analysis of 9 studies of ginkgo for use in the treatment of dementia concluded it was more effective than placebo, although, like other dementia drugs, the clinical significance of these moderate effects was difficult to quantify.
•  An editorial in The Lancet concluded ginkgo biloba does not prevent dementia in elderly individuals with or without memory complaints or cognitive impairment and is not effective for prevention of Alzheimer's disease